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Publications

Listed on this page are scientific publications by users of PPS or of the platforms at the respective founding university. Notify PPS of new publications where proteins from PPS have been used.

Publications 2025

1. Wang W, Mahboubi A, Zhu S, Hanson J, Mateus A, Niittyla T. Ribosome biogenesis in plants requires the nuclear envelope and mitochondria localized OPENER complex. Nat Commun. 2025;16(1):7301.

2. Vander Elst N, Farmen K, Knorr L, Merlijn L, Iovino F. Bacteriophage-derived endolysins restore antibiotic susceptibility in beta-lactam- and macrolide-resistant Streptococcus pneumoniae infections. Mol Med. 2025;31(1):170.

3. Trillo-Muyo S, Ermund A, Hansson GC. Structure of the MUC5AC VWD3 assembly responsible for the formation of net-like mucin polymers. EMBO Rep. 2025.

4. Trillo-Muyo S, Dolan B, Svensson F, Vickers TJ, Arike L, Garcia-Bonete MJ, et al. EatA mediated degradation of intestinal mucus is species-specific and driven by MUC2 structural features. Nat Commun. 2025;17(1):158.

5. Thakur B, Tarazi S, Dolezalová L, Behbahani H, Darreh-Shori T. Comparative Analysis of Cholinergic Machinery in Carcinomas: Discovery of Membrane-Tethered ChAT as Evidence for Surface-Based ACh Synthesis in Neuroblastoma Cells. International Journal of Molecular Sciences. 2025;26(21).

6. Sweetapple L, Kosek DM, Banijamali E, Becker W, Muller J, Karadiakos C, et al. Sequence, structure, and affinity of miR-34a binding sites determine repression efficacy. Nucleic Acids Res. 2025;53(13).

7. Sahl C, Chowdhury S, Malmstrom J, Pahlman LI. Antibody-guided identification of Achromobacter xylosoxidans protein antigens in cystic fibrosis. mSphere. 2025;10(5):e0023325.

8. Saczuk K, Cottini MV, Dudek M, Mazur LM, Sanchez DP, Lopez-Pacios L, et al. G-quadruplex-driven molecular disassembly and type I-to-type II photophysical conversion of a heavy-atom-free photosensitizer for site-specific oxidative damage. Nanoscale Horiz. 2025;10(8):1660-73.

9. Saamarthy K, Daams R, Sime W, Persson C, Chygorin E, Ahlqvist K, et al. An optimised Bcl-3 inhibitor for melanoma treatment. British Journal of Pharmacology. 2025;182(11):2426-46.

10. Puric E, Marinovic M, Kojek Z, Kahl-Knutson B, Leffler H, Nilsson UJ, et al. Design, synthesis, and evaluation of a novel fluorescent probe for competitive fluorescence polarization assay to screen galectin-8 inhibitors. Acta Pharmaceut. 2025;75(2).

11. Puric E, Hassan M, Sjovall F, Tomasic T, Pevec M, Lah J, et al. Nanomolar inhibitor of the galectin-8 N-terminal domain binds via a non-canonical cation-pi interaction. Commun Chem. 2025;8(1):59.

12. Patil KV, Sanz NC, Mak KH, Yang W, Annusver K, Makkar J, et al. The citrullinating enzyme PADI4 governs progenitor cell proliferation and translation in developing hair follicles. Sci Adv. 2025;11(37):eadx4511.

13. Morgunova E, Nagy G, Yin Y, Zhu F, Nayak SP, Xiao T, et al. Interfacial water confers transcription factors with dinucleotide specificity. Nat Struct Mol Biol. 2025.

14. Moller M, Jonsson M, Lundqvist M, Rockberg J, Lofblom J, Tegel H, et al. Deep sequencing combined with high-throughput screening enables efficient development of a pH-dependent high-affinity binding domain targeting HER3. Protein Sci. 2025;34(8):e70247.

15. Mattsson J, Rogne P, Landstrom M, Wolf-Watz M. Robust approach for production of the human oncology target Aurora kinase B in complex with its binding partner INCENP. Biochimie. 2025;229:129-40.

16. Mattsson J, Phoeurk C, Schierholz L, Mushtaq AU, Rodriguez Buitrago JA, Rogne P, et al. Exploring Helical Fraying Linked to Dynamics and Catalysis in Adenylate Kinase. Biochemistry. 2025;64(20):4281-95.

17. Marsh AJ, Pirogov S, Kaur Y, Ruffridge AJ, Sajwan S, Gibson TJ, et al. Catalytic-dependent and independent functions of the histone acetyltransferase CBP promote pioneer-factor-mediated zygotic genome activation. Mol Cell. 2025;85(12):2409-24 e8.

18. Mamia K, Kolbeinsdottir S, Labun K, Li Z, Komisarczuk A, Keskitalo S, et al. Precision T cell correction platform for inborn errors of immunity. Mol Ther. 2025;33(11):5624-43.

19. Magkakis K, Oradd F, Pett C, Lycksell M, Pounot K, Levantino M, et al. Addressing Structural Heterogeneity in Real-time Tracking of Protein Dynamics Triggered by Caged Compounds. J Mol Biol. 2025;437(24):169476.

20. Li QZ, Vlachos EN, Bryant P. Design of linear and cyclic peptide binders from protein sequence information. Communications Chemistry. 2025;8(1).

21. Kozielski F, Fisher SZ, Ma S, Al Busaidi F, Krupinska E, Nyblom M, et al. Structural basis for small molecule binding to the SARS-CoV-2 nsp10-nsp14 ExoN complex. Nucleic Acids Res. 2025;53(14).

22. Kolbeinsdottir S, Zachariadis V, Sommerauer C, Lohi O, Heinaniemi M, Enge M. Absolute copy number aware CNV calling of sub-megabase segments in ultra-low coverage single-cell DNA sequencing data. Nucleic Acids Res. 2025;53(17).

23. Kaustio M, Szymanska M, Li W, Braathen R, Campbell TM, Haugen FL, et al. Heterozygous loss of MAP4K1 causes immune dysregulation by amplifying T-cell responses. J Allergy Clin Immunol. 2025;156(4):1024-37.

24. Jonsson M, Moller M, Schierholz L, Dorka N, Tegel H, Lundberg E, et al. Engineered calcium-regulated affinity protein for efficient internalization and lysosomal toxin delivery. Proc Natl Acad Sci U S A. 2025;122(48):e2509081122.

25. Iliev P, Mccutcheon C, Admas TH, Reithmeier A, McDonald ML, van Outryve A, et al. Challenging the "Undruggable"-Targeting STAT3 but Identifying Potent TrkA-Targeted Inhibitors. Journal of Medicinal Chemistry. 2025;68(9):9501-24.

26. Guo P, Mao L, Chen Y, Lee CN, Cardilla A, Li M, et al. Multiplexed spatial mapping of chromatin features, transcriptome and proteins in tissues. Nat Methods. 2025;22(3):520-9.

27. Gulyas KV, Zhou L, Salamonsen D, Prester A, Bartels K, Bosman R, et al. Dynamically chiral phosphonic acid-type metallo-beta-lactamase inhibitors. Commun Chem. 2025;8(1):119.

28. Gulkis MC, Hodgkinson JT, Sele CP, Knecht W, McKenna R, Fisher SZ. Off-target binding of the histone deacetylase inhibitor vorinostat to carbonic anhydrase II and IX. Acta Crystallogr F Struct Biol Commun. 2025;81(Pt 9):388-97.

29. Gailleton R, Mathew NR, Reusch L, Schon K, Scharf L, Stromberg A, et al. Ectopic germinal centers in the nasal turbinates contribute to B cell immunity to intranasal viral infection and vaccination. Proc Natl Acad Sci U S A. 2025;122(12):e2421724122.

30. Fritsche M, Picozzi G, Nyman T, Zeberg H, Agren R. GNAI1 missense mutations associated with a neurodevelopmental syndrome modify Galpha(i1) function. Sci Signal. 2025;18(915):eadt8890.

31. Forslund JME, Nguyen TVH, Parkash V, Berner A, Goffart S, Pohjoismaki JLO, et al. The POLgamma Y951N patient mutation disrupts the switch between DNA synthesis and proofreading, triggering mitochondrial DNA instability. Proc Natl Acad Sci U S A. 2025;122(16):e2417477122.

32. Ehrencrona E, Gallego P, Trillo-Muyo S, Garcia-Bonete MJ, Recktenwald CV, Hansson GC, et al. The structure of FCGBP is formed as a disulfide-mediated homodimer between its C-terminal domains. FEBS J. 2025.

33. Dudek M, Lopez-Pacios L, Sabouri N, Nogueira JJ, Martinez-Fernandez L, Deiana M. A Rationally Designed Azobenzene Photoswitch for DNA G-Quadruplex Regulation in Live Cells. Angew Chem Int Ed Engl. 2025;64(1):e202413000.

34. Donev EN, Derba-Maceluch M, Liu XK, Bwanika HC, Dobrowolska I, Thapa M, et al. Glucuronoyl Esterase of Pathogenic Phanerochaete carnosa Induces Immune Responses in Aspen Independently of Its Enzymatic Activity. Plant Biotechnol J. 2025.

35. Dahlqvist A, Go RM, Kishor C, Leffler H, Blanchard H, Nilsson UJ. Synergy of triazolyl substituents at C1 and C3 of galactose for high-affinity and selective galectin-4C inhibition. RSC Chem Biol. 2025;6(9):1437-50.

36. Chen ZS, Huang HC, Wang X, Schon K, Jia Y, Lebens M, et al. Influenza A Virus H7 nanobody recognizes a conserved immunodominant epitope on hemagglutinin head and confers heterosubtypic protection. Nat Commun. 2025;16(1):432.

37. Carvalho G, Nguyen TVH, Repoles B, Forslund JME, Wijethunga W, Ranjbarian F, et al. Activating AMPK improves pathological phenotypes due to mtDNA depletion. FEBS J. 2025.

38. Berner B, Daoutsali G, Melen E, Remper N, Weszelovszka E, Rothnie A, et al. Successful strategies for expression and purification of ABC transporters. Biochim Biophys Acta Biomembr. 2025;1867(2):184401.

39. Baidya AT, Dante D, Das B, Wang L, Darreh-Shori T, Kumar R. Discovery and characterization of novel pyridone and furan substituted ligands of choline acetyltransferase. Eur J Pharmacol. 2025;998:177638.

40. Bader CPJ, Miyazaki-Kasho E, Forslund JME, Dash A, Wessels M, Wanrooij PH. The low endoribonuclease activity and lack of rNMP preference of human mitochondrial topoisomerase 1 protect against ribonucleotide-dependent deletions. Nucleic Acids Res. 2025;53(11).

41. B. Szakács TK, E. Juhász-Tóth, I. Cservenyák, I. Timári, U. J. Nilsson, L. A. Varga, T. Docsa, V. Molnár, L. Márton, A. Ábrahám, A. Kiss-Szikszai, J. József, L. Juhász, L. Somsák, and M. Tóth. A regioselective synthesis of 2,4-disubstituted 2H-1,2,3-triazoles by coupling of N-tosylhydrazones and anhydro-aldose tosylhydrazones with 4-substituted 1H-1,2,3-triazoles. ACS Omega. 2025.

42. Anwar MM, Meseguer S, Garcia-Rodriguez N, Krupinska E, Sele C, Rodriguez-Jimenez A, et al. NK-A 17E-233I: a novel competitive inhibitor of human dihydroorotate dehydrogenase (DHODH) for cancer therapy. J Exp Clin Cancer Res. 2025;44(1):292.

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